Definitions for zafirlukast
zafir·lukast

WiktionaryRate this definition:0.0 / 0 votes

1. zafirlukastnoun

   An oral leukotriene receptor antagonist for the maintenance treatment of asthma.

WikipediaRate this definition:0.0 / 0 votes

1. Zafirlukast

   Zafirlukast is an orally administered leukotriene receptor antagonist (LTRA) used for the chronic treatment of asthma. While zafirlukast is generally well tolerated, headache and stomach upset often occur. Some rare side effects can occur, which can be life-threatening, such as liver failure. Churg-Strauss syndrome has been associated with zafirlukast, but the relationship isn't thought to be causative in nature. Overdoses of zafirlukast tend to be self-limiting. Zafirlukast, like other LTRAs, works by inhibiting the immune system. Through its action on inflammatory cells in the lungs, zafirlukast reduces the production of inflammatory mediators that are implicated in the pathogenesis of asthma. Zafirlukast is extensively hepatically metabolized by an enzyme called CYP2C9. Zafirlukast inhibits the action of CYP3A4, leading to drug–drug interactions with other drugs that are metabolized by CYP3A4. Genetic differences in LTC4 synthase and CYP2C9 may predict how a person reacts to zafirlukast treatment. Zafirlukast (brand name Accolate) was the first cysteinyl leukotriene receptor antagonist approved in the United States. It is now approved in many other countries under other brand names.

WikidataRate this definition:0.0 / 0 votes

1. Zafirlukast

   Zafirlukast is an oral leukotriene receptor antagonist for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast, taken once daily. Zileuton, also used in the treatment of asthma via its inhibition of 5-lipoxygenase, is taken four times per day. Zafirlukast blocks the action of the cysteinyl leukotrienes on the CysLT1 receptors, thus reducing constriction of the airways, build-up of mucus in the lungs and inflammation of the breathing passages. Zafirlukast is marketed by Astra Zeneca with the brand names Accolate, Accoleit, and Vanticon. It was the first LTRA to be marketed in the USA and is now approved in over 60 countries, including the UK, Japan, Taiwan, Italy, Spain, Canada, Brazil, China and Turkey.

How to pronounce zafirlukast?

1. Alex

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   David

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   Mark

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   Daniel

   British

   Libby

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   Mia

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   Karen

   Australian

   Hayley

   Australian

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   Indian

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   Neerja

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   Zira

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   Oliver

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Numerology

1. Chaldean Numerology

   The numerical value of zafirlukast in Chaldean Numerology is: 2

2. Pythagorean Numerology

   The numerical value of zafirlukast in Pythagorean Numerology is: 9

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Zafirlukast
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Zafirlukast
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=zafirlukast