Definitions for toxication
tox·i·ca·tion

WiktionaryRate this definition:0.0 / 0 votes

1. toxicationnoun

   the metabolism of a drug or other compound to produce a toxic metabolite

WikipediaRate this definition:0.0 / 0 votes

1. Toxication

   Toxication, toxification or toxicity exaltation is the conversion of a chemical compound into a more toxic form in living organisms or in substrates such as soil or water. The conversion can be caused by enzymatic metabolism in the organisms, as well as by abiotic chemical reactions. While the parent drug are usually less active, both the parent drug and its metabolite can be chemically active and cause toxicity, leading to mutagenesis, teratogenesis, and carcinogenesis. Different classes of enzymes, such as P450-monooxygenases, epoxide hydrolase, or acetyltransferases can catalyze the process in the cell, mostly in the liver.Parent non-toxic chemicals are generally referred to as protoxins. While toxication is generally undesirable, in certain cases it is required for the in vivo conversion of a prodrug to a metabolite with desired pharmacological or toxicological activity. Codeine is an example of a prodrug, metabolized in the body to the active compounds morphine and codeine-6-glucuronide. Heavy metals are also the root cause for intoxication. Heavy metals such as lead, nickel, aluminium, cobalt, copper sometimes act as pseudo elements in biological system, the toxicity of heavy metal depends on the intake of the compounds present in the environment. Depending on the exposure and intake of the heavy metals there are two types of diseases i.e., acute and chronic. When a person starts accumulating heavy metals, leads to chronic disease like liver failure, heart diseases etc. Using pesticides is also one of the reason for the cause for toxication. Pesticides which possess elements like calcium, lead, copper, and zinc reside at the end of usage in the soil, which affects the fertility of the soil

WikidataRate this definition:0.0 / 0 votes

1. Toxication

   Toxication is the process of metabolism in which the metabolite of a compound is more toxic than the parent drug or chemical. A parent drug or chemical that was previously non-toxic may be called a protoxin. Toxication may involve: ⁕Changing the physicochemical properties to cause a change in the microenvironment ⁕Increasing the potency of a compound ⁕Conversion of the compound into: ⁕Electrophile ⁕Free radical ⁕Nucleophile ⁕Redox-active reactant While toxication is generally undesirable, in certain cases it is required for the in vivo conversion of a prodrug or chemical to a metabolite with desired pharmacological or toxicological activity. Codeine is an example of a prodrug, which is metabolized in the body to the opiate known as morphine.

How to pronounce toxication?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

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   Fred

   US English

   Tessa

   South African

How to say toxication in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of toxication in Chaldean Numerology is: 2

2. Pythagorean Numerology

   The numerical value of toxication in Pythagorean Numerology is: 4

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Toxication
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Toxication
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=toxication