Definitions for spironolactone
spirono·lac·tone

Princeton's WordNetRate this definition:0.0 / 0 votes

1. spironolactone, Aldactonenoun

   a synthetic corticosteroid (trade name Aldactone) used to treat hypertension

WiktionaryRate this definition:0.0 / 0 votes

1. spironolactonenoun

   A particular diuretic and antiandrogen.

WikipediaRate this definition:0.0 / 0 votes

1. Spironolactone

   Spironolactone, sold under the brand name Aldactone among others, is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. It is also used in the treatment of high blood pressure, low blood potassium that does not improve with supplementation, early puberty in boys, acne and excessive hair growth in women, and as a part of transgender hormone therapy in transfeminine people. Spironolactone is taken by mouth.Common side effects include electrolyte abnormalities, particularly high blood potassium, nausea, vomiting, headache, rashes, and a decreased desire for sex. In those with liver or kidney problems, extra care should be taken. Spironolactone has not been well studied in pregnancy and should not be used to treat high blood pressure of pregnancy. It is a steroid that blocks the effects of the hormones aldosterone and testosterone and has some estrogen-like effects. Spironolactone belongs to a class of medications known as potassium-sparing diuretics.Spironolactone was discovered in 1957, and was introduced in 1959. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. In 2020, it was the 51st most commonly prescribed medication in the United States, with more than 13 million prescriptions.

ChatGPTRate this definition:0.0 / 0 votes

1. spironolactone

   Spironolactone is a medication that belongs to a class of drugs known as aldosterone receptor antagonists, or more commonly known as a potassium-sparing diuretic. It is used to treat conditions such as high blood pressure, heart failure, edema (fluid retention), and hyperaldosteronism (a hormonal disorder). It works by blocking the action of aldosterone, a hormone in the body that affects the balance of salt and water in the body. By doing this, spironolactone helps the kidneys to remove more sodium and water from the body, while retaining more potassium.

WikidataRate this definition:0.0 / 0 votes

1. Spironolactone

   Spironolactone, commonly referred to simply as "spiro", and marketed primarily under the brand name Aldactone in most countries, is a synthetic, steroidal antimineralocorticoid agent with additional antiandrogen and weak progestogen properties, as well as some indirect estrogen and glucocorticoid effects, which is used primarily as a diuretic and antihypertensive, but also for the purpose of reducing elevated or unwanted androgen activity in the body. It acts predominantly as a competitive antagonist of the aldosterone receptor, and belongs to a class of pharmaceutical drugs known as potassium-sparing diuretics. Spironolactone is a relatively old drug, having been introduced clinically in 1959. It has been predicted that spironolactone will be superseded in cardiovascular conditions by the newer agents such as the structurally related compound eplerenone, which is also an aldosterone antagonist but is selective and lacks many of the actions and side effects of spironolactone, and as such is much more tolerable in comparison. However, spironolactone is still far more widely used than eplerenone. Spironolactone nonetheless still finds frequent use as an antiandrogen.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Spironolactone

   A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)

Matched Categories

1. • Antihypertensive
   • Corticosteroid

Usage in printed sourcesFrom: 

1. [["1948","5"],["1959","3"],["1960","68"],["1961","28"],["1962","157"],["1963","98"],["1964","203"],["1965","213"],["1966","174"],["1967","200"],["1968","394"],["1969","207"],["1970","326"],["1971","425"],["1972","449"],["1973","384"],["1974","592"],["1975","697"],["1976","880"],["1977","638"],["1978","1197"],["1979","1242"],["1980","1127"],["1981","892"],["1982","1097"],["1983","1148"],["1984","1492"],["1985","1492"],["1986","2214"],["1987","1378"],["1988","1298"],["1989","1334"],["1990","1515"],["1991","1416"],["1992","1400"],["1993","1190"],["1994","1502"],["1995","1363"],["1996","1440"],["1997","1946"],["1998","1587"],["1999","1573"],["2000","1969"],["2001","2086"],["2002","2512"],["2003","2568"],["2004","2961"],["2005","3749"],["2006","3231"],["2007","3472"],["2008","3255"]]

How to pronounce spironolactone?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say spironolactone in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of spironolactone in Chaldean Numerology is: 7

2. Pythagorean Numerology

   The numerical value of spironolactone in Pythagorean Numerology is: 5

Popularity rank by frequency of use

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=spironolactone
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Spironolactone
3. ^ Wikipedia
   https://en.wikipedia.org/wiki/Spironolactone
4. ^ ChatGPT
   https://chat.openai.com
5. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=spironolactone
6. ^ Usage in printed sources
   https://books.google.com/ngrams/graph?content=spironolactone