What does severe combined immunodeficiency disease mean?

Definitions for severe combined immunodeficiency disease
se·vere com·bined im·mun·od·e·fi·cien·cy dis·ease

This dictionary definitions page includes all the possible meanings, example usage and translations of the word severe combined immunodeficiency disease.

Princeton's WordNet

  1. severe combined immunodeficiency, severe combined immunodeficiency disease, SCIDnoun

    a congenital disease affecting T cells that can result from a mutation in any one of several different genes; children with it are susceptible to infectious disease; if untreated it is lethal within the first year or two of life

Wikipedia

  1. severe combined immunodeficiency disease

    Severe combined immunodeficiency (SCID), also known as Swiss-type agammaglobulinemia, is a rare genetic disorder characterized by the disturbed development of functional T cells and B cells caused by numerous genetic mutations that result in differing clinical presentations. SCID involves defective antibody response due to either direct involvement with B lymphocytes or through improper B lymphocyte activation due to non-functional T-helper cells. Consequently, both "arms" (B cells and T cells) of the adaptive immune system are impaired due to a defect in one of several possible genes. SCID is the most severe form of primary immunodeficiencies, and there are now at least nine different known genes in which mutations lead to a form of SCID. It is also known as the bubble boy disease and bubble baby disease because its victims are extremely vulnerable to infectious diseases and some of them, such as David Vetter, have become famous for living in a sterile environment. SCID is the result of an immune system so highly compromised that it is considered almost absent. SCID patients are usually affected by severe bacterial, viral, or fungal infections early in life and often present with interstitial lung disease, chronic diarrhea, and failure to thrive. Ear infections, recurrent Pneumocystis jirovecii (previously carinii) pneumonia, and profuse oral candidiasis commonly occur. These babies, if untreated, usually die within one year due to severe, recurrent infections unless they have undergone successful hematopoietic stem cell transplantation or gene therapy in clinical trials.

ChatGPT

  1. severe combined immunodeficiency disease

    Severe combined immunodeficiency disease (SCID) is a rare, life-threatening genetic disorder that weakens the immune system. This condition impairs the individual’s ability to defend against bacteria, viruses, and fungi, rendering them susceptible to severe and life-threatening infections. In cases of SCID, both aspects of the adaptive immune system, specifically the T and B lymphocytes, are impaired or non-functional. It is typically identifiable in infancy and requires strict isolation to avoid exposure to germs and infections. Without treatment, like stem cell transplant, gene therapy or enzyme replacement therapy, SCID is usually fatal within the first few years of life.

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Numerology

  1. Chaldean Numerology

    The numerical value of severe combined immunodeficiency disease in Chaldean Numerology is: 7

  2. Pythagorean Numerology

    The numerical value of severe combined immunodeficiency disease in Pythagorean Numerology is: 9

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"severe combined immunodeficiency disease." Definitions.net. STANDS4 LLC, 2024. Web. 5 Nov. 2024. <https://www.definitions.net/definition/severe+combined+immunodeficiency+disease>.

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