What does myxopyronin mean?
Definitions for myxopyronin
myx·opy·ronin
This dictionary definitions page includes all the possible meanings, example usage and translations of the word myxopyronin.
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Wiktionary
myxopyroninnoun
Any of several naturally-occurring antibiotics obtained from myxobacteria
Wikidata
Myxopyronin
Myxopyronin is an alpha-pyrone antibiotic, the first in a new class of inhibitors of bacterial RNA polymerase that target switch 1 and switch 2 of the RNAP "switch region." Rifamycin antibacterial agents, which are first-line treatments for tuberculosis, and lipiarmycin also target RNAP, but target different sites in RNAP. Myxopyronin does not have cross-resistance with rifamycins and lipiarmycin. Myxopyronin may be useful to address the growing problem of drug resistance in tuberculosis. It also may be useful in treatment of methicillin-resistant Staphylococcus aureus. It is in pre-clinical development and has not yet started clinical trials. Myxopyronin was first isolated in 1983 from a soil bacterium by Rolf Jansen and Herbert Irschik. A total synthesis of myxopyronin was first reported in 1998 by James S. Panek and co-workers. The target, the mechanism of action, and the structure of the complex of RNAP with myxopyronin were first reported in 2008 by Richard H. Ebright and co-workers. Novel analogs of myxopyronin have been synthesized at Anadys Pharmaceuticals and at Rutgers University. Terence I. Moy and co-workers at Cubist Pharmaceuticals have stated that, based on high resistance rate and high serum protein binding, the unmodified natural product myxopyronin B is not a viable starting point for antibiotic development.
Numerology
Chaldean Numerology
The numerical value of myxopyronin in Chaldean Numerology is: 1
Pythagorean Numerology
The numerical value of myxopyronin in Pythagorean Numerology is: 8
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"myxopyronin." Definitions.net. STANDS4 LLC, 2024. Web. 14 Nov. 2024. <https://www.definitions.net/definition/myxopyronin>.
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