Definitions for lafora's disease
lafo·ra's dis·ease

Princeton's WordNetRate this definition:5.0 / 1 vote

1. myoclonus epilepsy, Lafora's diseasenoun

   epilepsy characterized by clonus of muscle groups and progressive mental deterioration and genetic origin

WikipediaRate this definition:0.0 / 0 votes

1. lafora's disease

   Lafora disease is a rare, adult-onset and autosomal recessive genetic disorder which results in myoclonus epilepsy and usually results in death several years after the onset of symptoms. The disease is characterized by the accumulation of inclusion bodies, known as Lafora bodies, within the cytoplasm of the cells in the heart, liver, muscle, and skin.: 545  Lafora disease is also a neurodegenerative disease that causes impairment in the development of brain (cerebral) cortical neurons and is a glycogen metabolism disorder. Lafora disease (LD) was described by the Spanish Neuropathologist Gonzalo Rodríguez Lafora (1886-1971) in 1911, while directing the Neuropathology Section at the Government Hospital for Mental Insane (current NIH, USA) Lafora is a rare disease, meaning it is very rare in children, adolescents and adults worldwide. However, Lafora disease has a higher incidence among children and adolescents with ancestry from regions where consanguineous relationships are common, namely the Mediterranean (North Africa, Southern Europe), the Middle East, India, and Pakistan. Dogs can also have the condition. In dogs, Lafora disease can spontaneously occur in any breed, but the Miniature Wire Haired Dachshund, Bassett Hound, and the Beagle are predisposed to LD.Most human patients with this disease do not live past the age of twenty-five, and it often leads to death within ten years of symptoms appearing. Late onset symptoms of this disease can begin at any age depending on the genes affected. At present, there is no cure for this disease, but there are ways to deal with symptoms through treatments and medications.

ChatGPTRate this definition:0.0 / 0 votes

1. lafora's disease

   Lafora's disease, also known as Lafora progressive myoclonus epilepsy, is a rare, inherited, severe form of progressive myoclonus epilepsy. It is characterized by epilepsy, difficulty walking, muscle spasms, and dementia. The disease typically begins in late childhood or early adolescence and is caused by mutations in the EPM2A or NHLRC1 genes. Over time, this disease severely impairs neurological function and reduces life expectancy.

Matched Categories

1. • Epilepsy

How to pronounce lafora's disease?

1. Alex

   US English

   David

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   Mark

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   Daniel

   British

   Libby

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   Mia

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   Karen

   Australian

   Hayley

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   Natasha

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   Neerja

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   Zira

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   Oliver

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How to say lafora's disease in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of lafora's disease in Chaldean Numerology is: 2

2. Pythagorean Numerology

   The numerical value of lafora's disease in Pythagorean Numerology is: 8

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=lafora's disease
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Lafora's_Disease
3. ^ ChatGPT
   https://chat.openai.com