What does halofuginone mean?
Definitions for halofuginone
halofug·i·none
This dictionary definitions page includes all the possible meanings, example usage and translations of the word halofuginone.
Wiktionary
halofuginonenoun
A coccidiostat used in veterinary medicine; a synthetic halogenated derivative of febrifugine.
Wikidata
Halofuginone
Halofuginone is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb Dichroa febrifuga. Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and it has received orphan drug designation from the U.S. Food and Drug Administration. Halofuginone inhibits the development of T helper 17 cells, immune cells that play an important role in autoimmune disease, but it does not affect other kinds of T cells which involved in normal immune function. Halofuginone therefore has potential for the treatment of autoimmune disorders. Halofuginone is also an inhibitor of collagen type I gene expression and as a consequence it may inhibit tumor cell growth. Halofuginone exerts its effects by acting as a high affinity inhibitor of the enzyme Glutamyl-Prolyl tRNA synthetase. Inhibition of prolyl tRNA charging leads to the accumulation of uncharged prolyl tRNAs, which serve as a signal to initiate the amino acid starvation response, which in turn exerts anti-inflammatory and anti-fibrotic effects.
Numerology
Chaldean Numerology
The numerical value of halofuginone in Chaldean Numerology is: 2
Pythagorean Numerology
The numerical value of halofuginone in Pythagorean Numerology is: 1
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"halofuginone." Definitions.net. STANDS4 LLC, 2024. Web. 27 Dec. 2024. <https://www.definitions.net/definition/halofuginone>.
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