Definitions for cyclosporine
ˌsaɪ kləˈspɔr in, -ɪn, -ˈspoʊr-, ˌsɪk lə-; -ɪncy·closporine

GCIDERate this definition:0.0 / 0 votes

1. cyclosporinenoun

   a chemical substance produced by some soil fungi, which suppresses the cellular immune response by inhibiting T cell activation, and has been used in medicine to reduce foreign tissue rejection, especially subsequent to organ transplant surgery.

WiktionaryRate this definition:0.0 / 0 votes

1. cyclosporinenoun

   A cyclic oligopeptide, obtained from soil fungi, used as an immunosuppressive drug after an organ transplant.

WikipediaRate this definition:0.0 / 0 votes

1. cyclosporine

   Ciclosporin, also spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication. It is taken orally or intravenously for rheumatoid arthritis, psoriasis, Crohn's disease, nephrotic syndrome, and in organ transplants to prevent rejection. It is also used as eye drops for keratoconjunctivitis sicca (dry eyes).Common side effects include high blood pressure, headache, kidney problems, increased hair growth, and vomiting. Other severe side effects include an increased risk of infection, liver problems, and an increased risk of lymphoma. Blood levels of the medication should be checked to decrease the risk of side effects. Use during pregnancy may result in preterm birth; however, ciclosporin does not appear to cause birth defects.Ciclosporin is believed to work by decreasing the function of lymphocytes. It does this by forming a complex with cyclophilin to block the phosphatase activity of calcineurin, which in turn decreases the production of inflammatory cytokines by T-lymphocytes.Ciclosporin was isolated in 1971 from the fungus Tolypocladium inflatum and came into medical use in 1983. It is on the World Health Organization's List of Essential Medicines. In 2020, it was the 212th most commonly prescribed medication in the United States, with more than 2 million prescriptions. It is available as a generic medication.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Cyclosporine

   A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).

How to pronounce cyclosporine?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say cyclosporine in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of cyclosporine in Chaldean Numerology is: 3

2. Pythagorean Numerology

   The numerical value of cyclosporine in Pythagorean Numerology is: 1

Popularity rank by frequency of use

References

1. ^ GCIDE
   https://gcide.gnu.org.ua/?q=cyclosporine
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Cyclosporine
3. ^ Wikipedia
   https://en.wikipedia.org/wiki/Cyclosporine