Definitions for click chemistry
click chem·ist·ry

WiktionaryRate this definition:0.0 / 0 votes

1. click chemistrynoun

   A philosophy of chemistry in which substances are generated quickly and reliably by joining small modular units together, as in nature.

2. Etymology: Coined by Karl Barry Sharpless (1941-), American chemist, circa 2001.

WikipediaRate this definition:0.0 / 0 votes

1. Click chemistry

   In chemical synthesis, click chemistry is a class of simple, atom-economy reactions commonly used for joining two molecular entities of choice. Click chemistry is not a single specific reaction, but describes a way of generating products that follow examples in nature, which also generates substances by joining small modular units. In many applications, click reactions join a biomolecule and a reporter molecule. Click chemistry is not limited to biological conditions: the concept of a "click" reaction has been used in chemoproteomic, pharmacological, and various biomimetic applications. However, they have been made notably useful in the detection, localization and qualification of biomolecules. Click reactions occur in one pot, are not disturbed by water, generate minimal and inoffensive byproducts, and are "spring-loaded"—characterized by a high thermodynamic driving force that drives it quickly and irreversibly to high yield of a single reaction product, with high reaction specificity (in some cases, with both regio- and stereo-specificity). These qualities make click reactions particularly suitable to the problem of isolating and targeting molecules in complex biological environments. In such environments, products accordingly need to be physiologically stable and any byproducts need to be non-toxic (for in vivo systems). By developing specific and controllable bioorthogonal reactions, scientists have opened up the possibility of hitting particular targets in complex cell lysates. Recently, scientists have adapted click chemistry for use in live cells, for example using small molecule probes that find and attach to their targets by click reactions. Despite challenges of cell permeability, bioorthogonality, background labeling, and reaction efficiency, click reactions have already proven useful in a new generation of pulldown experiments (in which particular targets can be isolated using, for instance, reporter molecules which bind to a certain column), and fluorescence spectrometry (in which the fluorophore is attached to a target of interest and the target quantified or located). More recently, novel methods have been used to incorporate click reaction partners onto and into biomolecules, including the incorporation of unnatural amino acids containing reactive groups into proteins and the modification of nucleotides. These techniques represent a part of the field of chemical biology, in which click chemistry plays a fundamental role by intentionally and specifically coupling modular units to various ends. The term "click chemistry" was coined by K. Barry Sharpless in 1998, and was first fully described by Sharpless, Hartmuth C. Kolb, and M.G. Finn of The Scripps Research Institute in 2001. In 2022, the Nobel Prize in Chemistry was jointly awarded to Carolyn R. Bertozzi, Morten P. Meldal and K. Barry Sharpless, "for the development of click chemistry and bioorthogonal chemistry".

WikidataRate this definition:0.0 / 0 votes

1. Click chemistry

   Click chemistry was first fully described by K. Barry Sharpless of The Scripps Research Institute in 2001 and describes chemistry tailored to generate substances quickly and reliably by joining small units together. Click chemistry is not a single specific reaction, but was meant to mimic nature, which also generates substances by joining small modular units. A desirable Click chemistry reaction would: ⁕be modular ⁕be wide in scope ⁕give very high chemical yields ⁕generate only inoffensive byproducts ⁕be stereospecific ⁕be physiologically stable ⁕exhibit a large thermodynamic driving force to favor a reaction with a single reaction product. A distinct exothermic reaction makes a reactant "spring-loaded". ⁕have high atom economy. The process would preferably: ⁕have simple reaction conditions ⁕use readily available starting materials and reagents ⁕use no solvent or use a solvent that is benign or easily removed ⁕provide simple product isolation by non-chromatographic methods

How to pronounce click chemistry?

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How to say click chemistry in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of click chemistry in Chaldean Numerology is: 4

2. Pythagorean Numerology

   The numerical value of click chemistry in Pythagorean Numerology is: 5

Examples of click chemistry in a Sentence

1. Jon Lorsch:

   The original click chemistry used copper as a catalyst to join molecules, but the trouble is that copper is toxic to most living systems at higher concentrations.

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Click_Chemistry
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Click_Chemistry
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=click chemistry