What does bicuculline mean?
Definitions for bicuculline
bicu·culline
This dictionary definitions page includes all the possible meanings, example usage and translations of the word bicuculline.
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Wiktionary
bicucullinenoun
A light-sensitive competitive antagonist of GABA receptors; it is used in the study of epilepsy
Wikidata
Bicuculline
Bicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species. Since it blocks the inhibitory action of GABA receptors, the action of bicuculline mimics epilepsy. This property is utilized in laboratories across the world in the in vitro study of epilepsy, generally in hippocampal or cortical neurons in prepared brain slices from rodents. This compound is also routinely used to isolate glutamatergic receptor function. The action of bicuculline is primarily on the ionotropic GABAA receptors, which are ligand-gated ion channels concerned chiefly with the passing of chloride ions across the cell membrane, thus promoting an inhibitory influence on the target neuron. These receptors are the major targets for benzodiazepines and related anxiolytic drugs. The half-maximal inhibitory concentration of bicuculline on GABAA receptors is 3 μM. In addition to being a potent GABAA receptor antagonist, bicuculine can be used to block Ca2+-activated potassium channels. Sensitivity to bicuculline is defined by IUPHAR as a major criterion in the definition of GABAA receptors
U.S. National Library of Medicine
Bicuculline
Isoquinoline alkaloid from Dicentra cucullaria and other plants that is a competitive antagonist at GABA-A receptors and thus causes convulsions.
Numerology
Chaldean Numerology
The numerical value of bicuculline in Chaldean Numerology is: 2
Pythagorean Numerology
The numerical value of bicuculline in Pythagorean Numerology is: 3
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"bicuculline." Definitions.net. STANDS4 LLC, 2024. Web. 22 Dec. 2024. <https://www.definitions.net/definition/bicuculline>.
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